Nebivolol 99200-09-6

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Product Details:

Properties White to almost white crystalline powder; odorless; non-hygroscopic
Structural Formula Available on request
Solubility Slightly soluble in water, freely soluble in methanol and ethanol
Storage Store in cool, dry place away from light
Molecular Weight 405.44 g/mol
Product Type Active Pharmaceutical Ingredient
HS Code 29420090
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Nebivolol 99200-09-6 Product Specifications

Product Type Active Pharmaceutical Ingredient
Molecular Weight 405.44 g/mol
Storage Store in cool, dry place away from light
Structural Formula Available on request
Solubility Slightly soluble in water, freely soluble in methanol and ethanol
Properties White to almost white crystalline powder; odorless; non-hygroscopic
Poisonous Non-poisonous under approved use
Grade Pharmaceutical Grade
Taste Bitter
HS Code 29420090
Shelf Life 5 years if stored properly
Application Antihypertensive; used for treatment of high blood pressure
EINECS No 620-353-7
Usage For pharmaceutical formulations
Purity >=99% (HPLC)
Density 1.3 Gram per cubic centimeter(g/cm3)
Smell Odorless
Shape Crystalline
Melting Point 146-153C
Appearance White or almost white powder
Ingredients Nebivolol
CAS No 99200-09-6
Molecular Formula C22H25F2NO4
Physical Form Powder

Optical Activity Chiral compound
Heavy Metals 20 ppm
Packaging Sealed HDPE drum or customized packaging
Regulatory Status USP/EP Compliant
Impurity Level 0.1%
pKa ~9.3 (Basic)
Loss on Drying 0.5%

Nebivolol 99200-09-6 Trade Information

Main Export Market(s) Asia, Australia, Central America, North America, South America, Eastern Europe, Western Europe, Middle East, Africa

Product Description

General description:

Chemical Formula: C22H25F2NO4

Nebivolol is a beta blocker used to treat high blood pressure and heart failure. As with other B-blockers, it is generally a less preferred treatment for high blood pressure. It may be used by itself or with other blood pressure medication.

Application & Usage: Nebivolol is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. This medication belongs to a class of drugs known as beta-blockers. It works by blocking the action of certain natural substances in your body, such as epinephrine, on the heart and blood vessels. This effect lowers heart rate, blood pressure, and strain on the heart.

Packing 25 Kg HDPE Drums

Pharmaceutical Compliance and Purity

Nebivolol stands out due to its compliance with both USP and EP regulations, ensuring robust quality and safety for pharmaceutical formulation use. Its high purity (99%) and stringent impurity limits guarantee consistent therapeutic performance. The compound is non-poisonous when used as directed and is free from excessive heavy metal contamination, meeting the highest industry standards.

Optimal Handling and Storage

To retain Nebivolols pharmacological properties, it must be stored in sealed HDPE drums or custom packaging in a cool, dry area away from light. Proper storage preserves its non-hygroscopic and stable characteristics, maximizing its shelf life of up to five years. These measures ensure that the product remains in optimal condition for pharmaceutical applications.

FAQs of Nebivolol 99200-09-6:

Q: How should Nebivolol be used in pharmaceutical formulations?

A: Nebivolol is intended for antihypertensive therapy, incorporated into pharmaceutical products for oral administration. It is commonly formulated as tablets or capsules based on its validated clinical efficacy in lowering blood pressure.

Q: What storage conditions are recommended for Nebivolol?

A: Nebivolol must be kept in a sealed HDPE drum or customized packaging, stored in a cool, dry place away from direct light. This environment maintains its quality and extends its shelf life to five years.

Q: When is Nebivolol typically administered in medical practice?

A: Nebivolol is prescribed when blood pressure management is indicated, usually as determined by a healthcare professional. The dosing schedule and duration are tailored to the patients specific needs and medical assessment.

Q: Where is Nebivolol typically supplied from and what packaging options are available?

A: Nebivolol is exported globally by suppliers and traders based in India. Packaging includes standard sealed HDPE drums or can be customized according to buyer requirements to ensure safe transport and storage.

Q: What is the manufacturing process that ensures the purity and compliance of Nebivolol?

A: Nebivolol is produced under strict pharmaceutical manufacturing protocols, adhering to USP/EP standards. Quality control processes monitor heavy metals, impurities, and chemical stability, resulting in a product with 99% purity and 0.1% impurities.

Q: How does Nebivolol benefit patients with high blood pressure?

A: Nebivolol helps lower high blood pressure, thereby reducing the risk of cardiovascular complications like heart attack and stroke. Its selectivity for beta-receptors contributes to effective blood pressure control with fewer side effects.

Q: What key properties distinguish Nebivolol as a pharmaceutical ingredient?

A: Key features include its white crystalline, non-hygroscopic powder form, high purity, controlled impurity levels, low heavy metal content, and compliance with international pharmacopeia. Its stability, solubility profile, and safety under approved use further enhance its suitability for medicinal applications.

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